 increase in medication use increase in medication use 21 admin mon 10142019 1730 average and increase decrease of the number of medications used to treat a certain disease the indicator allows monitoring the increase or decrease in the number and use of drugs for treating a certain disease core quantitative disease  any harmful deviation from the normal structural or functional state of an organism drug supply  the distribution provision and or sale of health care products electronic medical records patient records calculate the average number of medications used for a certain disease provide the change increase decrease in the average number of medications used number in physical units outcome number of medications annually annually combining the data from different sources could be difficult yes extract from frahm et al 2018 p 5 available at  https wwwnaturecom articles s41598019402835 the indicator can also be provided in a graphic like in the example increase in drug supply 