<p><span><span><span><span><span><span><span><span><strong><span><span><span>Clinical guidelines: </span></span></span></strong></span></span><span><span><span><span><span><span>&nbsp;Statements that include recommendations, intended to optimize patient care, that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options (Institute of Medicine, 1990).</span></span></span></span></span></span></span></span></span></span></span></span></p>
