There are two alternative methods. The initiative/project can decide to provide one or both.
1) Specific for health research initiatives: Calculate the percentage that health gains and wider economics gain represent relative to the investment in medical research, with a lag between expenditure and outcomes, adjusting for inflation and discounting at a rate of 5% (More detailed information on how to calculate the ratio is provided in KPMG, Economic Impact of Medical Research in Australia (2018)).
2) General ROI: Calculate the percentage that the income generated by the initiative represents respect to the value of its assets.